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Clodronate Liposome And The Importance Of Its Discovery

By Roxanne Cruz


Before, thousands of residents die because certain medicine or vaccination was not yet available in the market. However, due to the discoveries of these geniuses, curing the once deadly diseases are now possible. Since medical science plays a very fascinating role in medicine science, clodronate liposome was discovered, accidentally. Because of the great role it plays in curing and treating diseases, it will surely be of great importance to medical science.

Clodronate also known as clodronate disodium and clodronic acid is a first generation non nitrogenous bisphosphonate. It is a drug scientifically approved, tested, and used to prevent and treat the cases of osteoporosis especially to the women who have reached the post menopausal period. It is also used in the experimental medicine to deplete macrophages.

Macrophages are white blood cells inside tissues. They are produced through division of monocytes, a type of white blood cell which was formed in the bone marrow and spleen which ingests particles of cell and huge foreign particles. So basically macrophage is the center of immune system. It defends the body from any invasion of different kinds of parasites and foreign transplant.

Liposomes, in cell biology, are the microscopic sac that are composed of fatty liquids. They are used in the experimental research of the cell. It can be supplied with drugs used in curing cancer and other diseases. It usually contained of liquid solutions and composed of phospholipids.

Science discovered clodronate liposome acts for the suppression of the macrophage. Indeed immune system defends the invasion of infectious viruses and bacteria. Through immune response, it will attack the invaders that will cause diseases to the organ or body. However, the immune system can be the source of disease in the body.

In natural circumstances, the healthy immune system will cope diseases up like coughs and colds. In the contrary, the damaged system will attack every cells it will eat each particles, both the healthy and damaged. When this doom happens, severe illnesses will take place affecting the body from functioning well.

The system protects the body from foreign invasion, as mentioned earlier. However, it will also create damages resulted by transplant rejection. This rejection happens when a a newly transplanted organ was placed in the body. As this happens, the system will attack the cells forcefully leading to rejection. One of the effects of the rejection is the autoimmune disorder or the identification of healthy cells wrongly and trying to fight off them because they thought that they are foreign.

Because of these cases that will damage the body defense against harmful organisms, doctors and scientists fumbled upon the discovery of liposome. This medicine is made of bisphosphonate that will help lessen the quantity of macrophage. As soon as macrophage detects that this drug transported inside the body is foreign, it will automatically engulf it whole through phagocytosis.

Clodronate liposome also helps to improve anti tumor effects caused by anti tumor drugs during cancer. This may not be able to cure the disease but somehow it will increase plasma absorption. Though this discovery is of great significance in the medical science, before actually resorting in taking it, consult you doctor first.




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